⁣A rancher threatens to disinherit his niece unless she stops seeing her boyfriend. When the rancher is found murdered, suspicion falls on her lover. Cisco and Pancho must find the real killer and clear the young man's name.

⁣Cisco and Pancho find a woman near death in the desert and learn she is a target for murder because she is headed for a ghost town to prove an inheritance and upon accompanying her find an addled innkeeper and other characters.

⁣ In order to break up a gang of vigilantes that are terrorizing the people of Buffalo Flats, Cisco and Pancho head into town disguised as a gambler and an organ grinder.

⁣ A crooked prosecutor robs quicksilver shipments, then uses chemical weapons to commit murder. Cisco and Pancho investigate.

⁣A pair of silver smugglers murder their partner, a local rancher, when he tries to back out of the operation. Cisco and Pancho set out to get them.

⁣Cisco is convinced by a beautiful woman that her brother, who escaped from prison, is trying to prove he was framed for a murder did not commit.

⁣Cisco and Poncho are being impersonated by two bandits who have committed robbery and murder, so they have to break jail to prove their innocence.

⁣The Sheriff in Bonanza orders his assistant to bring the murderer Jim Hardy to the state prison, where Hardy is going to be hanged. On the way the assistant is killed by a shot from a man, who releases Hardy and brings him to his boss, Jim Holbrook. Holbrook plans to kill his employer, the ranch owner Henry P. Murdock, and replace him with Hardy, who resembles Murdock. Through this switch, Holbrook will get control over the ranch himself.

⁣Joe Dawson, foreman at a ranch in San Saba, asks his old friend Cisco to come and help them catch a gang of cattle rustlers. When the leader of the gang hears of this, he orders two of his henchmen to kill Joe and blame the murder on Cisco. Cisco and Pancho have to keep away from the sheriff at the same as they are searching for the gang and the missing cattle.

⁣Cisco and Poncho are trapped by a ex pirate who runs a slave camp, with Indian guards, in a secret valley with his gorgeous niece who wants no part of it.

⁣Cisco takes part in an endurance race to help prove 4 quarter-horses can beat one thoroughbred, while the man entrusted to hold the race money, is planing to steal it.

⁣Cisco and Pancho get involved when a gang of jewel thieves, who've mailed themselves part of their haul, are prevented from getting their package by a by-the-book postal clerk, and they then decide to take it by force.

⁣Cisco and Pancho are forced to switch clothes with two escaped convicts, and are later arrested when they are mistaken for the fleeing criminals.

⁣Cisco and Pancho come across Bob Drake being chased by two outlaws. After helping him, Cisco hears his story of being framed for a gold robbery. Cisco believes Bob and decides to investigate.

⁣Cisco and Pancho come across the disrobed body of a railway inspector sent to a town to investigate shady real estate dealings in the name of the railway.

⁣A super fast on the draw, ex-con gets out of prison, and is bent on killing Cisco and Bill Shannon for sending him there.

⁣Cisco and Pancho try to find who has been sabotaging a woman's company freight wagons, before she looses the $20,000 performance bond she put up.

⁣Cisco and Pancho work with a sheriff and beautiful undercover female agent for the cattlemen's association, to break up a cattle rustling operation.

⁣When a wounded dog tracks down the man who murdered his master, a gold mine owner, Cisco tries to get proof he is the killer.

⁣ After having captured and jailed a bank robber, Pancho is then taken hostage by the robber's sister, who threatens to kill him unless Cisco frees her brother.