⁣At his remote laboratory in Zarpa Mesa in Mexico, a mad scientist seeks to create a master race of superwomen by injecting his subjects with spider venom!

⁣DESERT JUSTICE: U.S. Marshal Emmett Dowd arrives at the Ponderosa to take ranch hand Dave Walker to face trial in Los Angeles. Concerned by the way Dowd treats Walker, and believing the man to be innocent, Adam and Hoss decide to go along to make sure that Walker reaches Los Angeles alive.

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The Cartwrights, with Hop Sing, finish a cattle drive in San Francisco. Ben warns the other men of the dangers of the big city. Nevertheless, some of the men are careless and naive. Two of the hired hands disappear, and Ben suspects that the men were shanghaied. With invaluable assistance from several of Hop Sing's cousins, the Cartwrights locate the missing men and break up the racket.

⁣ Mr. Mooney foolishly allows Lucy to try on a $6,000 anniversary ring he bought for his wife. When it becomes stuck on her finger, Lucy takes some tranquilizers to help her relax. The pills make her loopy, leaving Mooney to drag around a semi-conscious redhead while trying to un-stick the ring.

⁣Lucy and Mooney appear in Pat Collins' hypnotist act.

⁣ Tired of hearing what a lousy employee she is, Lucy wants to prove to Mr. Mooney she could easily get another job. The employment agency tricks her into taking a high-paying babysitting gig. They don't bother to tell her she'll be taking care of three chimps whose "parents" treat them like little humans.

⁣ Annie thinks that an ex-con suspected of the recent robbery of a gold shipment has been framed.

⁣Tagg is initially dubious about the arrival of Lofty's young niece, until he finds that she is a tomboy with interests similar to his.

⁣A tenderfoot from Mississippi travels to Diablo to visit his sister and loses his watch in a stagecoach robbery. The headstrong youth is soon telling everyone how to do their jobs - including questioning Lofty's search for the outlaws who robbed him and his sister's experienced ranch foreman about his business methods. The young man really bites off more than he can chew when he discovers the identity of the thieves and tries to bring in the entire outlaw gang single-handed.

⁣Cisco and Pancho break a woman out of jail, after she has been sentenced to hang for a murder she did not commit.

⁣A grizzly bear follows Dusty back to the camp after our hero pulls a thorn from the bear's foot.

⁣Dusty and Callahan are arrested when a Calvary officer accuses them of stealing an army payroll.

⁣A young ranch hand tries to protect his girlfriend and her family of immigrant homesteaders from the attacks of his cowboy friends who want to keep the range open to run their cattle. .

⁣Joey signs up to ride in the Junior Rodeo. But he's up against the local champion, Ty Jones (played by Sammy Ogg). Jim, Pete, and Fury help Joey learn to ride a bucking bronco.

⁣Army payroll messengers are found dead, murdered by a gang of bandits, and the payroll stolen. In order to find the killers, Hawkeye and Chingachcook go undercover as managers of a local trading post.

⁣After Pat Garrett kills Billy the Kid, Billy's look-alike Roy Rogers arrives and is mistaken for him. Despite being a murderer, Billy was actively against large ranchers, protecting the homesteaders. Now, with Rogers in town, he seeks to continue Billy's fight, but without violence.

⁣ Rancher helps a friend claim a spread he's inherited, only to get involved in his murder.

⁣ Wishing to settle down, Fuzzy uses his reward money to buy a newspaper. He then raises money for the new telegraph line. When it is stolen, Barlowe incites the towns people to hang him. But his pal Billy Carson is at work to clear him.

⁣ Sintown is just a deserted ghost town until Vanerpool starts looking for silver. Cookie and Roy's partners put $20,000 into the business only to find that the mine is worthless and Vanerpool is bankrupt. Carol comes out to look for silver to save the company, but does not know that their engineer, named Regan, is crooked and wants all the silver for himself. But only Old Ed knows where the mother lode is located.

⁣Lambert owns the trucking line that ships cattle to market. When he raises his rates Roy decides to ship the cattle on the River Boat. When Lambert and his men are unable to stop the boat, they rustle the cattle.